Clonidine

pre-synaptic alpha-2 adrenoreceptor agonist

Uses:

  • prolonging duration of LA for nerve blocks/ epidural
  • sedation and analgesia in ICU
  • opiate and alcohol withdrawal
  • chronic pain, regional pain syndromes
  • hypertension
  • diagnosis of phaeochromocytoma

Caution:

  • Bradycardia
  • Hypotension
  • Sensitivity
  • Porphyria
  • May cause initial hypertension

Dose

  • IV: 1-5mcg/kg bolus (adult), 1-2mcg/kg bolus (paeds)
  • Epidural: 1mcg/kg (up to 150mcg)

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