CPP target range: 50 – 70 mm Hg
Patients with intact pressure auto-regulation tolerate higher target CPP
Based on:
Aggressive attempts to maintain CPP > 70 mm Hg risk pulmonary oedema, cardiac failure, ARDS (Level II evidence)
CPP < 50 mm Hg should be avoided (Level III evidence)
Brain Trauma Foundation Guidelines.
https://www.braintrauma.org/coma-guidelines/searchable-guidelines/