Tag Archives: sedation

Clonidine

pre-synaptic alpha-2 adrenoreceptor agonist

Uses:

  • prolonging duration of LA for nerve blocks/ epidural
  • sedation and analgesia in ICU
  • opiate and alcohol withdrawal
  • chronic pain, regional pain syndromes
  • hypertension
  • diagnosis of phaeochromocytoma

Caution:

  • Bradycardia
  • Hypotension
  • Sensitivity
  • Porphyria
  • May cause initial hypertension

Dose

  • IV: 1-5mcg/kg bolus (adult), 1-2mcg/kg bolus (paeds)
  • Epidural: 1mcg/kg (up to 150mcg)

Paeds infusions for sedation

Midazolom

Bolus: 0.1mg/kg = 100mcg/kg
Infusion: 1-4 mcg/kg/min

Syringe: 3 x BW (in mg) in 50ml
1ml/hr = 1mcg/kg/min
1ml = 0.06mg/kg = 60mcg/kg

Run at 1-4ml/hr

Morphine

Bolus: 0.1mg/kg = 100mcg/kg
Infusion: 10-40mcg/kg/hr

Syringe: BW (in mg) in 50ml
1ml/hr = 20mcg/kg/hr
1ml = 20mcg/kg

Run at 0.5-2ml/hr

Fentanyl

Bolus: 1-2 mcg/kg
Infusion: 2-8 mcg/kg/hr